A clinical trial to evaluate long-acting antiretroviral therapy (ART) for maintaining HIV suppression in people for whom adhering to conventional daily oral ART has been a challenge has begun at research sites across the United States. NIH Cabenuva, pending FDA approval, stands to impact HIV treatment in the U.S. Cabenuva would be the first injectable antiretroviral. Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs. Maturation inhibitor. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. The ATLAS-2M study examined reducing the frequency of dosing from 4-weekly to 8-weekly, the findings of which are reported by Edgar Overton and colleagues in The Lancet.1 They compared … Taylor BS, Olender SA, Tieu HV, Wilkin TJ. CROI 2014: Advances in antiretroviral therapy. CROI 2016: Advances in Antiretroviral Therapy. - New Data from International HIV/AIDS Society 2017. - New Data from International HIV/AIDS Society 2017. The … Nucleoside reverse transcriptase inhibitors (NRTIs) are important components of antiretroviral therapy (ART) when combined with other medications [1, 2]. The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). The association of NRTIs with short- and long-term side effects such as nausea, diarrhea, and lipodystrophy and the emergence of virus resistance have led to the search for NRTI-sparing regimens [ 3 , 4 ]. 2012 Jun-Jul;20(2):61-86. 2020 Dec 5;133(23):2775-2777. doi: 10.1097/CM9.0000000000001226. Long-acting injectable rilpivirine is not approved by … Theranostics. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. CROI 2018: Advances in Antiretroviral Therapy. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. NIH 2020 Dec 5;133(23):2775-2777. doi: 10.1097/CM9.0000000000001226. 2020 Jan 1;10(2):630-656. doi: 10.7150/thno.39847. HHS Epidemiologic data were reported on the prevalence, impact, regional variation, and changes over time of resistance-associated mutations. Ready for HIV Dual Therapy?  |   |  With long-acting injectable antiretroviral therapy likely to be a treatment option for people living with HIV (PLWH), it is critical to assess its acceptability among potential end-users. Decreasing regional and national rates of resistance may be a benefit of increasing use of integrase strand transfer inhibitors (InSTIs). The first long-acting injectable treatments for HIV were recommended for marketing approval on October 16 by the European Medicines Agency (EMA). Kevadiya BD, Ottemann B, Mukadam IZ, Castellanos L, Sikora K, Hilaire JR, Machhi J, Herskovitz J, Soni D, Hasan M, Zhang W, Anandakumar S, Garrison J, McMillan J, Edagwa B, Mosley RL, Vachet RW, Gendelman HE. Ready for HIV Dual Therapy? People who received a combination of two long-acting injectable antiretrovirals once a month expressed a high level of satisfaction with the regimen and almost all said they preferred it to their previous oral therapy, according to two studies presented yesterday at the 10th International AIDS Society Conference on HIV Science (IAS 2019) in Mexico City. 2020 Jan 1;10(2):630-656. doi: 10.7150/thno.39847. Olender S, Wilkin TJ, Taylor BS, Hammer SM. 2020 Oct;117:108058. doi: 10.1016/j.jsat.2020.108058.  |  USA.gov. LA ART may address key barriers to oral ART adherence and be preferable to daily pills for some people living with HIV. [Epub ahead of print] A Conjoint Analysis of the Acceptability of Targeted Long-Acting Injectable Antiretroviral Therapy Among Persons Living with HIV in the U.S. Simoni JM(1)(2), Tapia K(3), Lee SJ(4), Graham SM(3)(5), Beima-Sofie K(3), Mohamed ZH(3), Christodoulou J(4), Ho R(6), Collier AC(5). Taylor BS, Olender SA, Tieu HV, Wilkin TJ. Carlos del Rio, MD reviewing N Engl J Med 2019 Jul 24 Venter WDF et al. CROI 2014: Advances in antiretroviral therapy. 2019 Oct;311-312:201-211. doi: 10.1016/j.jconrel.2019.09.001. Antiretroviral therapy interrupts crucial steps of the HIV life cycle. eCollection 2020. Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery, Nature Communications (2019). The ATLAS-2M study examined reducing the frequency of dosing from 4-weekly to 8-weekly, the findings of which are reported by Edgar Overton and colleagues in . Based on the results of the phase 3 efficacy studies called ATLAS and FLAIR, we know that injectable CAB/RPV is safe, well-tolerated, and (among those who chose to participate in the studies), highly popular. Top Antivir Med. Please enable it to take advantage of the complete set of features! Advances and challenges in antiretroviral therapy for acquired immunodeficiency syndrome. Chin Med J (Engl). Likert scores of long-acting injectable antiretroviral therapy acceptability by proposed injection-site reaction duration. CROI 2016: Advances in Antiretroviral Therapy. J Control Release. Epidemiologic data were reported on the prevalence, impact, regional variation, and changes over time of resistance-associated mutations. AIDS Behav. To date, women have been less represented than men in LA ART research. Creation of a long-acting rilpivirine prodrug nanoformulation. Long-acting injectable antiretroviral therapy (ART) offers the convenience of reduced dosing frequency . These delivery systems may give patients the ability to administer daily medica­tion less frequently and allow in-clinic admin­istration for those who have not disclosed their status and do not want to bring medi­cation bottles home. Kevadiya BD, Ottemann B, Mukadam IZ, Castellanos L, Sikora K, Hilaire JR, Machhi J, Herskovitz J, Soni D, Hasan M, Zhang W, Anandakumar S, Garrison J, McMillan J, Edagwa B, Mosley RL, Vachet RW, Gendelman HE. The compound also exhibits activity against HIV-2. Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues. COVID-19 is an emerging, rapidly evolving situation. COVID-19 is an emerging, rapidly evolving situation. Shrestha R, DiDomizio EE, Kim RS, Altice FL, Wickersham JA, Copenhaver MM. New findings were presented on maternal and fetal health outcomes in women of reproductive potential, drug-drug interactions between hormonal contraception and ART, and further exploration of the association between InSTIs and birth defects.  |  4,5,6 Cabotegravir and rilpivirine are co-administered as two intramuscular (IM) injections in the buttocks by a Healthcare Professional at the … and, for the combination of the long-acting rilpivirine and cabotegravir, provides an additional two-drug ART option. Antiretroviral Therapy in 2019: Which Is the Best Regimen for the Global Roll-Out? A third were women, two thirds were white, about a quarter were black and the median age was 42 years. Awareness about and willingness to use long-acting injectable pre-exposure prophylaxis (LAI-PrEP) among people who use drugs. NLM eCollection 2020. J Subst Abuse Treat. Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. Test-and-treat … However, late diagnosis and mortality after ART initiation remain high, even in the context of HIV service scale-up, and mortality from unintentional opioid overdose in people living with HIV in the United States is on the rise. Please enable it to take advantage of the complete set of features! Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. J Subst Abuse Treat. Using in-depth interviews, this study sought to understand the experiences of PLHIV (n = 53) participating in Phase 3 LA ART trials in the United States and Spain. In appropriate combinations, it is so potent that plasma viral load is suppressed to levels undetectable by conventional assays. Test-and-treat and rapid-ART-start strategies show promise in advancing progress toward the HIV care cascade 90-90-90 Joint United Nations Programme on HIV/AIDS/World Health Organization targets. This strategy — two injections every 4 or 8 weeks — obviates the need to take antiretroviral therapy daily. In FLAIR, people who were treatment-naive were started on abacavir/dolutegravir/lamivudine (Triumeq) and, if they achieved viral suppression at 20 weeks, were randomized to either stay on this oral regimen or add oral CAB and RPV (to demonstrate … HHS First long-acting injectable antiretroviral therapy for HIV recommended for approval EMA has recommended the granting of marketing authorisations for two new antiretroviral (ARV) medicines, Rekambys (rilpivirine) and Vocabria injection (cabotegravir), to be used together for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection. Would you like email updates of new search results? Investigators presented a case report of a second patient possibly cured of HIV through an allogeneic hematopoietic stem cell transplant from a CC chemokine receptor 5-delta 32 donor. Long-acting injectable antiretroviral therapy (LA ART) may be an alternative for people living with HIV (PLHIV) with adherence challenges or who prefer not to take pills. Emerging alternative antiretroviral (ARV) delivery systems for HIV treatment and prevention include injectables, topicals, and implants. Marketing Authorisation is based on the pivotal phase III ATLAS (Antiretroviral Therapy as Long-Acting Suppression), FLAIR (First Long-Acting Injectable Regimen) and ATLAS-2M studies, which included more than 1,200 participants from 16 countries. 2019 Oct 26. doi: 10.1007/s10461-019-02701-7. Clipboard, Search History, and several other advanced features are temporarily unavailable. N Engl J Med 2019 Jul 24 Havlir DV and Doherty MC. Clipboard, Search History, and several other advanced features are temporarily unavailable. Among a list of presented options for primary preferred distribution venue for an injectable antiretroviral, a clear majority selected the clinician’s office (115, 57%) as their preferred venue. Epub 2019 Sep 3. This site needs JavaScript to work properly. 2016 May-Jun;24(1):59-81. Whilst ART does not cure HIV and AIDS, and should therefore be taken for life, it dramatically reduces mortality and morbidity if used appropriately. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. More information: S. Rahima Benhabbour et al.  |  Published on Nov 22, 2019 The session outlines a study that evaluates Long Acting Injectable Antiretroviral Therapy (LA ART) as a solution to … At baseline, half were taking NNRTI-based regimens, a third were taking integrase inhibitors and 17% were o… Epub 2020 Jun 15. Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. This has led to the concept of “HAART”, which literally means using very … The data supporting a regimen consisting of injectable CAB/RPV were presented at CROI 2019 in the form of a pair of open-label trials named FLAIR and ATLAS. The study, called Long-Acting Therapy to Improve Treatment Success in Daily Life, or LATITUDE, will help determine whether a combination of two experimental injectable … Using longitudinal data from the Women’s Interagency HIV Study (WIHS) … Long-acting injectable antiretroviral therapy (ART) offers the convenience of reduced dosing frequency and, for the combination of the long-acting rilpivirine and cabotegravir, provides an additional two-drug ART option. EDURANT® (rilpivirine) is a once daily non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of human immunodeficiency virus (HIV-1) infection in combination with other antiretroviral agents in antiretroviral treatment-naïve patients 12 years of age and older and weighing at least 35-kg with a viral load ≤ 100,000 HIV RNA copies/mL. Top Antivir Med. CROI 2019: Antiretroviral Therapy Volume 27 Issue 1 April 2019 against a broad range of HIV-1 resistant to other ART classes including those with Gag polymorphisms conferring resistance to maturation inhibitors. Shrestha R, DiDomizio EE, Kim RS, Altice FL, Wickersham JA, Copenhaver MM. The global ATLAS (Antiretroviral Therapy as Long-Acting Suppression) and FLAIR (First Long-Acting Injectable Regimen) pivotal phase 3 studies included more than 1,100 patients from 16 countries and concluded that the combination of cabotegravir and rilpivirine, injected monthly, was as effective as a daily, oral, three-drug regimen in maintaining viral suppression throughout the 48-week study period. Epub 2019 Sep 3. The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). Read on to learn more about the new drug and what to consider ahead of its potential arrival in early 2021. This site needs JavaScript to work properly. “ We found that long-acting injectable antiretroviral therapy was a compelling option among the women we interviewed.” The researchers conducted 59 in-depth interviews with women living with HIV in six Women’s Interagency HIV Study (WIHS) sites: New York, Chicago, Washington DC, Atlanta, Chapel Hill, and San Francisco, from November 2017 to October 2018. J Control Release. 2016 May-Jun;24(1):59-81. N Engl J Med 2019 Jul 24. Epub 2020 Jun 15. Hilaire JR, Bade AN, Sillman B, Gautam N, Herskovitz J, Dyavar Shetty BL, Wojtkiewicz MS, Szlachetka A, Lamberty BG, Sravanam S, Fox HS, Alnouti Y, Dash PK, McMillan JM, Edagwa BJ, Gendelman HE. Creation of a long-acting rilpivirine prodrug nanoformulation. Long-acting (LA) injectable antiretroviral therapy (ART) has been found non-inferior to daily oral ART in Phase 3 trials. The ATLAS trial, presented by Swindells, included 616 treatment-experienced patients. Two clinical trials of long-acting injectable cabotegravir and rilpivirine showed promising safety, efficacy, and tolerability as maintenance ART. DeJesus and col-leagues presented data from a phase antiretroviral therapy (ART) has revolutionized the care and management of HIV and AIDS and has transformed the disease from being life-threatening infection into a chronic and manageable condition. Based on formative qualitative work and our own ongoing development of targeted long-acting products in nanosusp … Test-and-treat and rapid-ART-start strategies show promise in advancing progress toward the HIV care cascade 90-90-90 Joint United Nations Programme on HIV/AIDS/World Health Organization targets. EMA has recommended the granting of marketing authorisationsfor two new antiretroviral (ARV) medicines, Rekambys (rilpivirine) and Vocabria injection (cabotegravir), to be used together for the treatment of patients with human immunodeficiency virus type 1 (HIV-1) infection. Advances and challenges in antiretroviral therapy for acquired immunodeficiency syndrome. Theranostics. Would you like email updates of new search results? Weight gain following the initiation of antiretroviral therapy (ART) has been reported across multiple settings and study populations. Decreasing regional and national rates of resistance may be a benefit of increasing use of integrase strand transfer inhibitors (InSTIs).  |  Top Antivir Med. Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues. In vitro studies were presented that identified and evaluated the effect of resistance-associated mutations on ART susceptibility and elucidated mechanisms of resistance. Two studies done in Sub-Saharan Africa suggest that dolutegravir-based antiretroviral therapy is noninferior to efavirenz–based ART but is … Top Antivir Med. Chin Med J (Engl). NLM USA.gov. They had been on antiretroviral therapy for a median of four years, all had viral suppression and the median CD4 count was 653 cells/mm3. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). The 2019 Conference on Retroviruses and Opportunistic Infections included many exciting advances in antiretroviral therapy (ART). Olender S, Wilkin TJ, Taylor BS, Hammer SM. Author information: … New findings were presented on maternal and fetal health outcomes in women of reproductive potential, drug-drug interactions between hormonal contraception and ART, and further exploration of the association between InSTIs and birth defects. More information: Morgan M. Philbin et al, A Qualitative Exploration of Women's Interest in Long-Acting Injectable Antiretroviral Therapy Across … In vitro studies were presented that identified and evaluated the effect of resistance-associated mutations on ART susceptibility and elucidated mechanisms of resistance. Marketing Authorisation is based on the pivotal phase III ATLAS (Antiretroviral Therapy as Long-Acting Suppression), FLAIR (First Long-Acting Injectable Regimen) and ATLAS-2M studies, which included more than 1,200 participants from 16 countries. 2020 Oct;117:108058. doi: 10.1016/j.jsat.2020.108058. However, late diagnosis and mortality after ART initiation remain high, even in the context of HIV service scale-up, and mortality from unintentional opioid overdose in people living with HIV in the United States is on the rise. Levels undetectable by conventional assays among people who use drugs in vitro studies were presented that identified and the... 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